个人简介

宋中迪博士，山东聊城人，讲师，工学博士。天津大学生物化工专业硕士，英国伦敦大学学院(UCL)生物化工专业博士，曾获UCL海外研究生奖学金(ORS)。主要从事光合微藻生物技术和酶分子改造研究工作，围绕生物炼制和合成生物学概念，先后开展了蓝藻抗逆机制、硅藻生理生化、微藻放大培养及下游生物工艺、酶分子改造及检测等相关研究。现阶段主要从事1）针对新污染物，探究微藻环境分子毒理与微藻修复(phycoremediation)机制；2）酶分子改造推进绿色生物制造。

宋中迪博士已在Molecular & Cellular Proteomics, Algal Research, Frontier in Bioengineering and Biotechnology, International Journal of Biological Macromolecules, Bioresources and Bioprocessing等期刊上发表SCI论文13篇，以第一/通讯作者发表SCI论文4篇。

主要科研成果

论文

[13] Wang L, Liu K, Song Z, Do H, Yang L, Wu J, Jiang L, Yu H. Influence of coordination number and ionic radius on metal ion preference and activity of lanthanide-dependent alcohol dehydrogenase: Insights from mutational studies and density functional theory. Colloids Surf B Biointerfaces. 2025, 251:114596.

[12] Pu Z, Cao J, Wu W, Song Z, Yang L, Wu J, Yu H. Reconstructing dynamics correlation network to simultaneously improve activity and stability of 2,3-butanediol dehydrogenase by design of distal interchain disulfide bonds. Int J Biol Macromol. 2024, 267(Pt 2):131415.

[11] Liu K, Jiang L, Ma S, Song Z*, Wang L, Zhang Q, Xu R, Yang L, Wu J, Yu H*. An evolved pyrrolysyl-tRNA synthetase with polysubstrate specificity expands the toolbox for engineering enzymes with incorporation of noncanonical amino acids. Bioresour Bioprocess. 2023, 10(1):92.

[10] Zhang Q, Zheng W, Song Z, Zhang Q, Yang L, Wu J, Lin J, Xu G, Yu H. Machine Learning Enables Prediction of Pyrrolysyl-tRNA Synthetase Substrate Specificity. ACS Synth Biol. 2023, 12(8):2403-2417.

[9] Song Z, Zhang Q, Wu W, Pu Z, Yu H. Rational design of enzyme activity and enantioselectivity. Front Bioeng Biotechnol. 2023, 11:1129149.

[8] Ji C, Song Z, Tian Z, Feng Z, Fan L, Shou C, Zhao M. Enantioselectivity in the toxicological effects of chiral pesticides: A review. Sci Total Environ. 2023, 857(Pt 3):159656.

[7] He J, Wang Z, Zhen F, Wang Z, Song Z, Chen J, Hrynsphan D, Tatsiana S. Mechanisms of flame retardant tris (2-ethylhexyl) phosphate biodegradation via novel bacterial strain Ochrobactrum tritici WX3-8. Chemosphere. 2023, 311(Pt 2):137071.

[6] Song Z, Lye GJ, Parker BM. Morphological and biochemical changes in Phaeodactylum tricornutum triggered by culture media: Implications for industrial exploitation. Algal Res. 2020, 47:101822.

[5] Sun T, Xu L, Wu L, Song Z, Chen L, Zhang W. Identification of a New Target slr0946 of the Response Regulator Sll0649 Involving Cadmium Tolerance in Synechocystis sp. PCC 6803. Front Microbiol. 2017, 8:1582.

[4] Song Z, Chen L, Wang J, Lu Y, Jiang W, Zhang W. A transcriptional regulator Sll0794 regulates tolerance to biofuel ethanol in photosynthetic Synechocystis sp. PCC 6803. Mol Cell Proteomics. 2014, 13(12):3519-32.

[3] Chen L, Zhu Y,Song Z, Wang J, Zhang W. An orphan response regulator Sll0649 involved in cadmium tolerance and metal homeostasis in photosynthetic Synechocystis sp. PCC 6803. J Proteomics. 2014, 103:87-102.

[2] Chen L, Wu L, Zhu Y, Song Z, Wang J, Zhang W. An orphan two-component response regulator Slr1588 involves salt tolerance by directly regulating synthesis of compatible solutes in photosynthetic Synechocystis sp. PCC 6803. Mol Biosyst. 2014, 10(7):1765-74.

[1] Zhu H, Ren X, Wang J, Song Z, Shi M, Qiao J, Tian X, Liu J, Chen L, Zhang W. Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystis sp. PCC 6803. Biotechnol Biofuels. 2013, 6(1):106.

科研项目

[1]Y202147851，浙江省教育厅一般科研项目，2021.10-2024.10，主持；

[2]Y22B070545，浙江省自然科学基金一般项目，2022.01-2024.12，参与