个人简介

郭子立博士，山东枣庄人，特聘副研究员，工学学士、医学硕士、医学博士。她是浙江工业大学药物化学专业博士，环境科学与工程博士后，长期从事中药成分分析及药效物质基础等相关领域的研究工作。

在此前的研究工作中，她主持浙江省科技计划-重点研发项目（子课题）1项，浙江省教育厅科研项目1项，参与国家自然科学基金1项，国家其它科技项目1项，浙江省自然科学基金1项，浙江省科技计划项目2项。以项目技术负责人承担横向课题2项，参与横向项目研究10余项。参与翻译《早期药物开发 将候选药物推向临床》和《药物靶点发现与确证》2本著作。

郭子立博士已在J Hazard Mater, Food Chem, J Food Compos Anal等学术刊物发表第一作者或共同第一作者论文15篇，参与发表论文9篇，并参与申请中国发明专利2项。

主要科研成果

论文

[1] Guo, Z.L., Zhou,L.F., Li, H.L., Huang, Y.H., Xu, C., Niu, L.L.*, 2025. Phytochemical analysis and safety evaluation of the extracts from Tetrastigma hemsleyanum Diels et Gilg leaves. Journal of Food Composition and Analysis 142, 107536.

[2] Guo, Z.L., Gao, X.Y., Wang, C.Y., Liu,S.R., Xu, C., Mao, S.D., Sun, X.H., Niu, L.L.*, Liu, W.P., 2024. Isomer, enantiomer and compound-specific stable isotope evidences for the transformation of dichlorodiphenyltrichloroethanes (DDTs) in soils from three typical paddy fields in China. Journal of Hazardous Materials 476, 135233.

[3]He, Y.F., Xiang, J.N., Chen, J., Fang, S., Guo, Z.L.*, Liang, X.R.*, 2023. Improving Bioaccessibility and Bioavailability of Isoflavone Aglycones from Chickpeas by Germination and Forming β-Cyclodextrin Inclusion Complexes. Pharmaceutics 15, 2684.

[4]Han, N., Ye, Q., Guo, Z.L., Liang, X.R.*, 2023. Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinaria L. root, stem, leaf and fruit. Natural Product Research 37(4), 642-645.

[5] Guo, Z.L.^#, Liu, Y.L.^#, Xiang, J.N., Liang, X.R.*, 2023. Mechanochemical preparation of red clover extract/β-cyclodextrin dispersion: Enhanced water solubility and activities in alleviating high-fat diet-induced lipid accumulation and gut microbiota dysbiosis in mice. Food Chemistry 420, 136084.

[6] Guo, Z.L., Chen, L.S., Liang, X.R.*, 2023. Components research on Tetrastigma hemsleyanum Diels et Gilg: Identification and effect of drying methods on the content of ten main constituents by targeting metabolomics method. Journal of Pharmaceutical and Biomedical Analysis 229, 115375.

[7] Guo, Z.L., Gu, J.P., Zhang, M., Su, F., Su, W.K., Xie, Y.Y.*, 2023. NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells. Biomolecules 13, 600.

[8] Guo, Z.L., Lai, J.X., Wu, Y.W., Fang, S., Liang, X.R.*, 2023. Investigation on Antioxidant Activity and Different Metabolites of Mulberry (Morus spp.) Leaves Depending on the Harvest Months by UPLC–Q-TOF-MS with Multivariate Tools. Molecules 28, 1947.

[9] Guo, Z.L., Gao, B.B., Fan, M.L., Chen, L.S., Zhang, C.J., Liang, X.R., Su, W.K., Xie, Y.Y.*, 2023. Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer’s Disease in Rats by LC-MS/MS. Molecules 28, 2377.

[10] Guo, Z.L., Zhu, P.X., He, X.A., Yan, T.H., Liang, X.R.*, 2021. Components identification and isomers differentiation in pigeon pea (Cajanus cajan L.) leaves by LC-MS. Journal of Separation Science 44(13), 2510–2523.

[11] Guo, Z.L., Cheng, J.Y., Zheng, L., Xu, W.H., Xie, Y.Y.*, 2021. Mechanochemical-assisted extraction and hepatoprotective activity research of flavonoids from sea buckthorn (Hippophaë rhamnoides L.) pomaces. Molecules 26(24), 7615.

[12] Guo, Z.L., Xiong, S.T., Xie, Y.Y., Liang, X.R.*, 2021. The separation and purification of ellagic acid from Phyllanthus urinaria L. by a combined mechanochemical-macroporous resin adsorption method. Separations 8(10), 186.

[13] Xia, J.J.^#, Guo, Z.L.^#, Fang, S., Gu, J.P., Liang, X.R.*, 2021. Effect of drying methods on volatile compounds of burdock (Arctium lappa L.) root tea as revealed by gas chromatography mass spectrometry-based metabolomics. Foods 10(4), 868.

[14] Han, N., Ye, Q., Guo, Z.L., Liang, X.R.*, 2023. Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinarial L. root, stem, leaf and fruit. Natural Product Research 37(4), 642–645.

[15] Jiang, X.L., Chen, S.H., Guo, Z.L., Gu, D., Liang, X.R.*, 2021. Components characterisation of Berchemia lineata (L.) DC. by UPLC-QTOF-MS/MS and its metabolism with human liver microsomes. Natural Product Research 35(3), 521–524.

[16] Liang, X.R., Jiang, Y., Guo, Z.L., Fang, S.*, 2020. Separation, UPLC-QTOF-MS/MS analysis, and antioxidant activity of hydrolyzable tannins from water caltrop (Trapa quadrispinosa) pericarps. LWT - Food Science and Technology 133, 110010.

[17] Guo, J.N., Mi, Z.S., Jiang, X.Y., Zhang, C.J., Guo, Z.L., Li, L.Z., Gu, J.P., Zhou, T., Bai, R.R. Xie, Y.Y.*, 2021. Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects. Bioorganic Chemistry 108, 104564.

[18] 郭子立, 夏骏杰, 韩宁, 顾金苹, 苏凤, 梁现蕊, 谢媛媛*, 2020. 猫须草UPLC指纹图谱的建立及其抗氧化活性研究. 发酵科技通讯49(4), 187–191.

科研项目

[1] 氨基酸衍生物及相关中间体分析方法的开发(2024KJ035)，杭州创引化工科技有限公司/横向，2024.01-2025.01，10万，主持、结题。

[2] SGLT-2抑制剂-列净类化合物过氧化物的合成及杂质研究（2024KJ294），杭州迈世腾药物科技有限公司/横向，2024.11-2026.12，30万，主持、在研。

[3] 基于肠道微生态调控的麻杏石甘汤干预支原体肺炎作用机制及药效物质基础研究（2024XZ001）, 浙江树人学院高端预研项目, 2024.01-2025.12，5万，主持、在研。

[4] 基于液质联用和细胞代谢组学技术研究二陈汤活性物质, 浙江工业大学绿色制药技术与装备 教育部重点实验室开放基金, 2023.12-2025.12，4万，主持、在研。

[5] 基于细胞代谢-质谱动态组学技术研究二陈汤活性物质 (2023R024), 浙江树人大学引进人才科研启动项目, 2023.05-2026.05，10万，主持、在研。

[6] 工业菌种基因组结构重排技术体系的创建（2021YFC2100800），国家重点研发计划子课题，2021.07-2024.07，138万，参与、结题；

[7] 候选药物开发研究-基于 MAO-B 和生物铁代谢多靶点新型抗阿尔兹海默病候选药物的研发（2021C03085），浙江省重点研发项目子课题，2021.01-2023.12，100万，主持、结题；

[8] 三叶青多糖的提取、纯化及结构表征（Y202043200），浙江省教育厅科研项目，2021.01-2022.12，1.25万，主持、结题。